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KMID : 0378019650080110049
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New Medical Journal
1965 Volume.8 No. 11 p.49 ~ p.58
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THE TREATMENT OF EARLY SYPHILIS IN KOREA
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Abstract
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For the purpose of an adequate schedule of treatment of early syphilis in Korea, the results of patients who had been treated in The Dermatology Clinic of St. Mary´s Hospital, Catholic Medical College, Seoul, Korea from January 1963 to September 1964 were analyzed.
Among 189 patients having early syphilis 99 were treated which 0.9 to 1.2 mega units of procaine penicillin for 20 days, or 4 doses of 2.4 to 3.0 mega units of benzathine penicillin at weekly intervals.
The symptoms and signs of early syphilis, except the positive serologic reaction, had completely disappeared within one week using the daily dose of 0.6 to 0.9 mega units of procaine penicillin.
A single dose of 2.4 to 3.0 mega units of benzathine penicillin also was followed by the same clearance of symptoms.
Observations of serologic conversion of patients who were treated are still being made. To date 60 per cent of positive reactions of the serologic tests for syphilis have been converted into a nonreactive VDRL tests after one year of treatments, 40 per cent of the RPCF testshave been converted after 6 months.
In the treatment of syphilis in Korean patients larger amounts of penicillin are needed than listed in the schedule recommended by the WHO in 1953 and the U.S. Public Health Service in 1960.
This is due to the inproper use of penicillin before the patients visited to the hospital.
The clinical use of benzathine penicillin for 4 times can be recommended as more satisfactory than procaine penicillin which had to be given daily.
Also benzathine penicillin has a longer repository action, requires less patient-time in the hospital and also is more economical.
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